HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy
نویسندگان
چکیده
منابع مشابه
HER2-Targeted Polyinosine/Polycytosine Therapy Inhibits Tumor Growth and Modulates the Tumor Immune Microenvironment.
The development of targeted therapies that affect multiple signaling pathways and stimulate antitumor immunity is greatly needed. About 20% of patients with breast cancer overexpress HER2. Small molecules and antibodies targeting HER2 convey some survival benefits; however, patients with advanced disease succumb to the disease under these treatment regimens, possibly because HER2 is not complet...
متن کاملHER2 Testing and Correlation With Efficacy of Trastuzumab Therapy
As a result of the availability and clinical efficacy of trastuzumab (Herceptin), clinicians are now faced with a dilemma regarding the accurate identification of patients with HER2 overexpression. In the October 2002 issue of ONCOLOGY, Monica Fornier and colleagues critically reviewed the methodologies currently available for HER2 testing in their article, "HER2 Testing and Correlation With Ef...
متن کاملHER2 testing and correlation with efficacy of trastuzumab therapy.
The need for accurate detection of HER2 status is becoming more apparent, as therapeutic decisions are influenced by this information in both the adjuvant and advanced-stage setting. Since the US Food and Drug Administration approved trastuzumab (Herceptin) for the treatment of metastatic breast cancer, the urgency of accurately evaluating HER2 status of breast cancer specimens, in order to ide...
متن کاملHER2 signaling regulates HER2 localization and membrane retention
ErbB2/HER2/Neu is a receptor tyrosine kinase that is overexpressed in 25-30% of human breast cancers, usually associated with amplification of the ERBB2 gene. HER2 has no recognized ligands and heterodimers between HER2 and EGFR (ErbB1/HER1) or HER2 and ErbB3/HER3 are important in breast cancer. Unlike other ErbB family members, HER2 is resistant to internalization and degradation, and remains ...
متن کاملMonitoring immune responses in the tumor microenvironment.
Immune monitoring in the tumor microenvironment allows for important insights into immune mechanisms of response and resistance to various cancer treatments; however clinical challenges exist using current strategies. Significant questions remain regarding monitoring of archival versus fresh tissue, assessment of static versus dynamic markers, evaluation of limited tissue samples, and the trans...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2018
ISSN: 2162-402X
DOI: 10.1080/2162402x.2018.1512942